abstract：:Natural cytotoxicity receptors and NKG2D correspond to major activating receptors involved in triggering of tumor cell lysis by human NK cells. In this report, we investigated the expression of NKG2D ligands (NKG2DLs), MHC class I-related chain (MIC) A, MICB and UL16-binding proteins 1, 2 and 3, on a panel of human no...

journal_title：International immunology

authors： Le Maux Chansac B,Missé D,Richon C,Vergnon I,Kubin M,Soria JC,Moretta A,Chouaib S,Mami-Chouaib F

更新日期：2008-07-01 00:00:00

abstract：:The aim of this in vitro study was to evaluate if osteoclasts (OCs) and dendritic cells (DCs), both of monocyte origin, can support the survival of normal human plasma cells (PCs). PCs differentiate from plasmablasts (PBs) arising from activated B cells, essentially memory B cells. To study the survival of both PBs (C...

journal_title：International immunology

authors： Geffroy-Luseau A,Jégo G,Bataille R,Campion L,Pellat-Deceunynck C

更新日期：2008-06-01 00:00:00

abstract：:Notch2 and Delta-like 1 (Dll1) have been implicated in the development of marginal zone B (MZB) cells. In the present study, we characterized the expression and function of mouse Notch receptors and ligands in the spleen by using newly generated mAbs. Although Notch2 was expressed on both B and T cells in the spleen, ...

journal_title：International immunology

authors： Moriyama Y,Sekine C,Koyanagi A,Koyama N,Ogata H,Chiba S,Hirose S,Okumura K,Yagita H

更新日期：2008-06-01 00:00:00

abstract：:Lymphocytes circulate in a quiescent (G(0)) state until they encounter specific antigens. In T cells, quiescence is programmed by transcription factors of the forkhead box O (FOXO) and Krüppel-like factor (KLF) families. However, the transcription factors that regulate B cell quiescence are not known. KLF4 is a candid...

journal_title：International immunology

authors： Yusuf I,Kharas MG,Chen J,Peralta RQ,Maruniak A,Sareen P,Yang VW,Kaestner KH,Fruman DA

更新日期：2008-05-01 00:00:00

abstract：:The immunomodulator FTY720 inhibits lymph node (LN) and thymic egress, thereby constraining T cell circulation and reducing peripheral T cell numbers. Here, we analyzed in mouse models the as yet scarcely characterized impact of long-term (up to 6 months) FTY720 exposure on T cell homeostasis and possible consequences...

journal_title：International immunology

authors： Metzler B,Gfeller P,Wieczorek G,Li J,Nuesslein-Hildesheim B,Katopodis A,Mueller M,Brinkmann V

更新日期：2008-05-01 00:00:00

abstract：:The production of IgE, a main player in allergic disorders such as asthma and atopic dermatitis, is strictly regulated and the serum concentrations of IgE are normally kept at a much lower level than other isotypes. We found that mice deficient for the p85alpha regulatory subunit of class IA phosphoinositide 3-kinase ...

journal_title：International immunology

authors： Doi T,Obayashi K,Kadowaki T,Fujii H,Koyasu S

更新日期：2008-04-01 00:00:00

abstract：:Trypanosoma cruzi, the agent of Chagas disease contains a major cysteine proteinase, cruzipain (Cz), with an unusual carboxyl-terminal extension (C-T). We have previously reported the presence of sulfate groups in the N-linked oligosaccharide chains of this domain. In order to evaluate the immune responses to sulfated...

journal_title：International immunology

authors： Acosta DM,Arnaiz MR,Esteva MI,Barboza M,Stivale D,Orlando UD,Torres S,Laucella SA,Couto AS,Duschak VG

更新日期：2008-04-01 00:00:00

abstract：:Heat shock protein (Hsp) 60 is thought to function as endogenous danger signal by activating professional antigen-presenting cells (APC) through toll-like receptor (TLR) 4 and CD14, a mechanism that is also used by bacterial LPS. We recently showed that Hsp60 binds LPS and enhances LPS-induced immune stimulation. On t...

journal_title：International immunology

authors： Osterloh A,Veit A,Gessner A,Fleischer B,Breloer M

更新日期：2008-03-01 00:00:00

abstract：:Under physiological conditions immune complexes (IC) are efficiently cleared from the circulation and meanwhile provide important feedback signals for the immune system via Fc gamma Rs and complement receptors. Dysregulation of these mechanisms have been implicated in conditions where IC concentrations reach pathologi...

journal_title：International immunology

authors： Isaák A,Gergely P Jr,Szekeres Z,Prechl J,Poór G,Erdei A,Gergely J

更新日期：2008-02-01 00:00:00

abstract：:Naive CD4(+) T cells rapidly proliferate to generate effector cells after encountering an antigen and small numbers survive as memory T cells in preparation for future immunological events. In the present work, adoptive transfer of naive CD4(+) T cells into RAG2(-/-) mice caused the generation of memory-type effector ...

journal_title：International immunology

authors： Noguchi D,Wakita D,Tajima M,Ashino S,Iwakura Y,Zhang Y,Chamoto K,Kitamura H,Nishimura T

更新日期：2007-12-01 00:00:00

abstract：:Metazoan species, from sponges to insects and mammals, possess successful defence systems against their pathogens and parasites. The evolutionary origins of these diverse systems are beginning to be more comprehensively investigated and mapped out. We have collected 1811 metazoan immunity genes from literature and gen...

journal_title：International immunology

authors： Rannikko K,Ortutay C,Vihinen M

更新日期：2007-12-01 00:00:00

abstract：:Lactic acid bacteria (LAB) are abundant in the gastrointestinal tract where they continuously regulate the immune system. NK cells are potently activated by dendritic cells (DCs) matured by inflammatory stimuli, and NK cells are present in the gut epithelium and in mesenteric lymph nodes, but it is not known how NK-DC...

journal_title：International immunology

authors： Fink LN,Zeuthen LH,Christensen HR,Morandi B,Frøkiaer H,Ferlazzo G

更新日期：2007-12-01 00:00:00

abstract：:The CC chemokine receptor 7 (CCR7) and its two ligands, CCL21 and CCL19, play an important role in migration of immune cells to lymphoid tissue. To analyze the function of CCR7 in T cell immunity to infectious agents in vivo, transgenic (tg) mice expressing CCL21 in an ubiquitous fashion were generated. These mice con...

journal_title：International immunology

authors： Unsoeld H,Mueller K,Schleicher U,Bogdan C,Zwirner J,Voehringer D,Pircher H

更新日期：2007-11-01 00:00:00

abstract：:After activation, populations of antigen-specific T cells flow between sites of antigen expression, local lymphoid structures and other lymphoid and non-lymphoid organs. In this study, we documented the in vivo dynamics of a CD8(+) T cell response to antigen delivered using herpes simplex virus amplicon vectors and re...

journal_title：International immunology

authors： Azadniv M,Dugger K,Bowers WJ,Weaver C,Crispe IN

更新日期：2007-10-01 00:00:00

abstract：:Myelin proteolipid protein (PLP) 139-151 is an immunodominant peptide that induces experimental autoimmune encephalomyelitis (EAE) in H-2(s) SJL/J mice. While PLP 139-151-specific TCR transgenic (tg) 4E3 mice develop fulminant spontaneous disease on the susceptible SJL/J background, spontaneous EAE is dramatically red...

journal_title：International immunology

authors： Illés Z,Waldner H,Reddy J,Anderson AC,Sobel RA,Kuchroo VK

更新日期：2007-10-01 00:00:00

abstract：:Autoimmune gastritis is a CD4+ T cell-mediated disease induced in genetically susceptible mice by thymectomy on the third day after birth. Previous linkage analysis indicated that Gasa1 and Gasa2, the major susceptibility loci for gastritis, are located on mouse chromosome 4. Here we verified these linkage data by sho...

journal_title：International immunology

authors： Ang DK,Brodnicki TC,Jordan MA,Wilson WE,Silveira P,Gliddon BL,Baxter AG,van Driel IR

更新日期：2007-09-01 00:00:00

abstract：:Src homology region 2-domain-containing phosphatase-1 (SHP-1) plays an important role in the regulation of signaling from various receptors in hematopoietic cells. In mast cells, SHP-1 has been shown to negatively regulate the initial signaling triggered by high-affinity receptor for IgE (FcepsilonRI) and positively r...

journal_title：International immunology

authors： Ozawa T,Nakata K,Mizuno K,Yakura H

更新日期：2007-09-01 00:00:00

abstract：:Neural stem cells (NSCs) transplantation has been proposed as a means of restoring damaged brain tissue, a possibility rendered more likely by reports of low NSCs immunogenicity in various experimental models because of low expression of MHC class I and II as well as co-stimulatory molecules. We investigated the immun...

journal_title：International immunology

authors： Ubiali F,Nava S,Nessi V,Frigerio S,Parati E,Bernasconi P,Mantegazza R,Baggi F

更新日期：2007-09-01 00:00:00

abstract：:We have found that FOXP3 is an oligomeric component of a large supramolecular complex. Certain FOXP3 mutants with single amino acid deletions in the leucine zipper domain of FOXP3 are associated with the X-linked autoimmunity-allergic dysregulation (XLAAD) and immunodysregulation, polyendocrinopathy and enteropathy, X...

journal_title：International immunology

authors： Li B,Samanta A,Song X,Iacono KT,Brennan P,Chatila TA,Roncador G,Banham AH,Riley JL,Wang Q,Shen Y,Saouaf SJ,Greene MI

更新日期：2007-07-01 00:00:00

abstract：:Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. Because of the wide range of ligand distribution in the body, its b...

journal_title：International immunology

authors： Okazaki T,Honjo T

更新日期：2007-07-01 00:00:00

abstract：:Schnurri (Shn)-2 is a large zinc finger-containing protein, which plays a critical role in cell growth, signal transduction and lymphocyte development. In Shn-2-deficient (Shn-2(-/-)) CD4 T cells, the activation of nuclear factor-kappaB is up-regulated and their ability to differentiate into Th2 is enhanced. Here, we ...

journal_title：International immunology

authors： Iwamura C,Kimura MY,Shinoda K,Endo Y,Hasegawa A,Yamashita M,Nakayama T

更新日期：2007-06-01 00:00:00

abstract：:The T cell Ig domain and mucin domain (TIM) proteins form a conserved family of transmembrane cell-surface glycoproteins expressed by a variety of tissues. Each TIM protein contains a single V-type Ig domain, a glycosylated mucin-like domain, a transmembrane domain and a cytoplasmic domain. TIM proteins recognize a di...

journal_title：International immunology

authors： Wilker PR,Sedy JR,Grigura V,Murphy TL,Murphy KM

更新日期：2007-06-01 00:00:00

abstract：:Dendritic cells (DCs) act as a first-line recognition system for invading pathogens, such as influenza A. The interaction of DC with influenza A virus results in DC activation via endosomal Toll-like receptors and also leads to presentation of viral peptides on MHC class II molecules. Prior work demonstrated that infl...

journal_title：International immunology

authors： Burster T,Giffon T,Dahl ME,Björck P,Bogyo M,Weber E,Mahmood K,Lewis DB,Mellins ED

更新日期：2007-05-01 00:00:00

abstract：:Streptococcus suis capsular type 2 is an important swine pathogen and an agent of zoonosis. Although meningitis is the most common form of disease, septicemia and septic shock are also frequently reported. Despite reports that CD14 is involved in the recognition of encapsulated S. suis by host cells, the mechanisms un...

journal_title：International immunology

authors： Graveline R,Segura M,Radzioch D,Gottschalk M

更新日期：2007-04-01 00:00:00

abstract：:Blocking T cell co-stimulatory signals by anti-B7-1/B7-2 mAb is an attractive approach to treat autoimmune diseases. However, anti-B7-1/B7-2 mAb treatment is known to exacerbate autoimmune diseases through mechanisms not fully understood. Tumor necrosis factor alpha (TNF-alpha) and reactive oxygen species (ROS) also p...

journal_title：International immunology

authors： Khan N,Ghousunnissa S,Jegadeeswaran SM,Thiagarajan D,Hasnain SE,Mukhopadhyay S

更新日期：2007-04-01 00:00:00

abstract：:Naturally occurring CD4(+)CD25(+) regulatory T cells (nT(R)) comprise a separate lineage of T cells that are essential for maintaining immunological tolerance to self. Here we demonstrate that the level of phosphorylation of the TCR zeta-chain is approximately 1.5- to 4-fold higher in nT(R) as compared with CD4(+)CD25...

journal_title：International immunology

authors： Andersson J,Stefanova I,Stephens GL,Shevach EM

更新日期：2007-04-01 00:00:00

abstract：:The chicken represents the best-characterized animal model for B cell development in the so-called gut-associated lymphoid tissue (GALT) and the molecular processes leading to B cell receptor diversification in this species are well investigated. However, the mechanisms regulating B cell development and homeostasis in...

journal_title：International immunology

authors： Kothlow S,Morgenroth I,Graef Y,Schneider K,Riehl I,Staeheli P,Schneider P,Kaspers B

更新日期：2007-02-01 00:00:00

abstract：:Members of protein kinase D (PKD) family serine/threonine kinases (PKD1, PKD2 and PKD3) are expressed in wide range of cells and regulate various cellular responses including immune responses. We have previously shown that PKD is involved in the signaling pathways of a human CD4(+) T cell clone stimulated with its cog...

journal_title：International immunology

authors： Irie A,Harada K,Tsukamoto H,Kim JR,Araki N,Nishimura Y

更新日期：2006-12-01 00:00:00

abstract：:The invertebrate pattern-recognition protein named coelomic cytolytic factor (CCF) and the mammalian cytokine tumor necrosis factor (TNF) share functional analogies that are based on a similar saccharide recognition specificity. In particular, CCF and TNF have been shown to interact with ion channels on the surface of...

journal_title：International immunology

authors： Bilej M,Josková R,Van den Bergh R,Procházková P,Silerová M,Ameloot P,De Baetselier P,Beschin A

更新日期：2006-12-01 00:00:00

abstract：:Several cytokines and chemokines including chemokine (C-C motif) ligand-2 (CCL2) are induced in HIV-1 infection. However, the impact of HIV-1 viremia on CCL2 regulation is largely unknown. We utilized a DNA oligonucleotide microarray covering 110 inflammatory genes. Five genes were induced by at least 2-fold in PBMCs ...

journal_title：International immunology

authors： Ansari AW,Bhatnagar N,Dittrich-Breiholz O,Kracht M,Schmidt RE,Heiken H

更新日期：2006-10-01 00:00:00

abstract：:House dust mite (HDM) is a common allergen of allergic asthma. Eosinophils are principal effector cells of allergic inflammation and their adhesion onto human bronchial epithelial cells is mediated by a CD18-intracellular adhesion molecule-1 (ICAM-1)-dependent interaction. We studied the effects of HDM Dermatophagoide...

journal_title：International immunology

authors： Wong CK,Li ML,Wang CB,Ip WK,Tian YP,Lam CW

更新日期：2006-08-01 00:00:00

abstract：:CD4 T cells are not thought to play a significant role in generating an effective primary CD8 T cell response to most viral infections. We have challenged this view by demonstrating that antigen-specific CD4 T cells can indeed suppress the proliferation of antigen-specific naive CD8 T cells in response to low doses of...

journal_title：International immunology

authors： Cose S,Brammer C,Zammit DJ,Blair DA,Lefrançois L

更新日期：2006-08-01 00:00:00

abstract：:Neutrophils and lymphocytes are recruited to sites of inflammation and require the adhesion molecule L-selectin (CD62L) for adherence to endothelial cells. Nucleotides released from activated or dying cells at sites of inflammation can mediate signaling through purinergic receptor family II, resulting in CD62L sheddin...

journal_title：International immunology

authors： Sengstake S,Boneberg EM,Illges H

更新日期：2006-07-01 00:00:00

abstract：:NK cells limit the emergence of cancers and viral infections by surveillance of 'missing-self' and 'induced-self' ligands, and by direct recognition of pathogen-associated molecules. We examined individual roles for Toll-like receptors (TLRs)-7 and -8 in human NK-cell activation using synthetic, small molecule agonist...

journal_title：International immunology

authors： Gorski KS,Waller EL,Bjornton-Severson J,Hanten JA,Riter CL,Kieper WC,Gorden KB,Miller JS,Vasilakos JP,Tomai MA,Alkan SS

更新日期：2006-07-01 00:00:00

abstract：:The chaperone glucose-regulated protein 94 (GRP94) has long been used to augment peptide presentation to T cells. This chaperone binds antigenic peptides, binds to receptors on professional antigen-presenting cells (APCs), activates these cells and after internalization, transfers the peptides to MHC class I for activ...

journal_title：International immunology

authors： Biswas C,Sriram U,Ciric B,Ostrovsky O,Gallucci S,Argon Y

更新日期：2006-07-01 00:00:00

abstract：:Incomplete T cell antigen receptor-mediated signaling induces an unresponsive state known as anergy. Previously, we had shown that anergy can be induced in antigen-primed but not naive T cells. In this report, we found that in vitro primed T cells from IL-2R alpha-deficient mice were resistant to anergy induction in c...

journal_title：International immunology

authors： Hayashi RJ,Kanagawa O

更新日期：2006-05-01 00:00:00

abstract：:Eye-derived antigen-presenting cells (APCs) are known to contribute to the immune privilege status of the eye by inducing a form of peripheral tolerance that deviates T(h)1 type of pro-inflammatory immune responses. Similar systemic tolerance can also be induced by non-ocular APCs exposed to transforming growth factor...

journal_title：International immunology

authors： Masli S,Turpie B,Streilein JW

更新日期：2006-05-01 00:00:00

abstract：:Auto-antibodies against heat shock proteins (HSPs) are frequently found in the sera of patients with rheumatic and other autoimmune diseases. However, it is unclear whether these auto-antibodies play a role in the pathophysiology and etiology of these diseases. We found that a murine anti-HSP60 mAb enhanced the produc...

journal_title：International immunology

authors： Yokota S,Minota S,Fujii N

更新日期：2006-04-01 00:00:00

abstract：:We have evaluated the capacity of a novel, nanoparticle-based tumor vaccine to eradicate established tumors in mice. C57BL/6 mice were intradermally (i.d.) inoculated with ovalbumin (OVA)-expressing EG-7 tumor cells. When the tumor size reached 7-8 mm, the tumor-bearing mice were i.d. injected near the tumor-draining ...

journal_title：International immunology

authors： Wakita D,Chamoto K,Zhang Y,Narita Y,Noguchi D,Ohnishi H,Iguchi T,Sakai T,Ikeda H,Nishimura T

更新日期：2006-03-01 00:00:00

abstract：:CD45 is a receptor tyrosine phosphatase essential for TCR signaling. One isoform, CD45RB, is down-regulated in memory cells and targeting CD45RB with a specific antibody has been shown to inhibit graft rejection. Its role in immunity to infection, however, has not been tested. Here, we report the effect of anti-CD45RB...

journal_title：International immunology

authors： Lim B,Sutherland RM,Zhan Y,Deliyannis G,Brown LE,Lew AM

更新日期：2006-02-01 00:00:00